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TREATMENTS FOR PRURITUS
Unlike pain, for which a host of effective medications are available, there are no general-purpose, consistently beneficial antipruritic drugs. The mechanisms, uses, and adverse effects of currently available antipruritic drug treatments are outlined in Table 5.5. A number of new and emerging therapies for atopic dermatitis provide ways to treat itch by targeting the neuro-immune interface. These include agents that block IL-4/-13 and IL-31 signaling as well as JAK inhibitors. Additional pruritus treatments are likely to result from further advances in our understanding of itch biology.
Table 5.5 Drug treatment of pruritus.