๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
INTRODUCTION
Psoriasis is an immune-mediated polygenic skin disorder. Various environmental triggering factors, e.g. trauma, infections, medications, may elicit disease in predisposed individuals. The characteristic lesion is a sharply demarcated erythematous plaque with micaceous scale, and the plaques may be localized or widespread in distribution. Histologically, hyperkeratosis, parakeratosis, acanthosis of the epidermis, tortuous and dilated vessels, and an inflammatory infiltrate composed predominantly of lymphocytes are observed.
Psoriasis is a systemic disease process in which up to 20%โ30% of patients have or will develop psoriatic arthritis. In addition, in patients with moderate to severe psoriasis, there is an increased relative risk for metabolic syndrome, atherosclerotic cardiovascular disease, and depression. Psoriasis also has a significant impact on patientsโ quality of life, and in surveys, patients feel that the current treatments, although often effective, do not provide a satisfactory long-term solution.