Introduction
Lorenzo Cerroni and Isabella Fried B Cell Lymphomas of the Skin
Synonyms: Cutaneous B cell lymphomas Skin-associated lymphoid tissue (SALT)-related B cell lymphomas
Key features
Cutaneous B cell lymphomas represent a group of lymphomas whose primary site is the skin; they are derived from B lymphocytes in different stages of differentiation. The skin can also be the site of secondary involvement by extracutaneous (usually nodal) B cell lymphomas
Most primary cutaneous B cell lymphomas (>80%) are low-grade malignancies, and they are characterized by indolent behavior and a good prognosis
Precise classification can be achieved only after a complete synthesis of clinical, histopathologic, immunophenotypic, and molecular features. The WHO-EORTC and ICC classifications provide the basis for a consistent classification of patients
Treatment options for low-grade types include primarily “watchful waiting”, intralesional corticosteroids and local radiotherapy; when solitary lesions are present, surgical excision is an option. Systemic or intralesional anti-CD20 antibody may be used in some patients, while systemic chemotherapy is only required in patients with high-grade tumors