๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
LEUKOTRIENE (LT) INHIBITORS
Initially identified as the slow-reacting substance of anaphylaxis, leukotrienes play a key role in systemic and cutaneous inflammatory reactions. Primarily used for the treatment of asthma, leukotriene inhibitors have been explored in a myriad of dermatologic conditions, including atopic dermatitis, urticaria, autoimmune bullous diseases, and SjรถgrenโLarsson syndrome. These inhibitors include montelukast
(Singulairยฎ), zafirlukast (Accolateยฎ), and pranlukast (Ultairยฎ), which block LTC, LTD and LTE, as well as zileuton (Zyflo CRยฎ) which inhibits 5-lipoxygenase (Table 130.11).
Fig. 130.6 Hydroxyurea-induced mucocutaneous changes.A Lower extremity ulcerations. B Hyperpigmentation of the oral mucosa. B, Courtesy Brian Horvath, MD.
Table 130.10 Hydroxyurea. CBC, complete blood count with differential and platelet count; CMP, comprehensive metabolic panel (includes liver function tests); HGB, hemoglobin; UA, urinalysis; WBC, white blood count.
Table 130.11 Leukotriene inhibitors. LFTs, liver function tests.