Introduction
Herbert Hönigsmann† and Thomas Schwarz Ultraviolet Therapy 134
Key features
Phototherapy represents the use of ultraviolet (UV) radiation for the treatment of skin diseases
Currently, phototherapy encompasses irradiation with broadband
UVB (290–320 nm), narrowband UVB (311–313 nm), 308 nm excimer laser, UVA1 (340–400 nm), UVA (320–400 nm) plus psoralens (PUVA) or alone, and extracorporeal photochemotherapy (photopheresis)
Therapeutic success depends upon proper selection of the
phototherapy modality for a given disease
Proper dosimetry is required to avoid acute side effects such as a sunburn reaction, blistering, and burning sensations
The risk of skin carcinogenesis represents the major long-term side effect of phototherapy; with the exception of PUVA, the magnitude of this risk is not yet clearly delineated