๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
HISTORY
One of the earliest documented irritant skin reactions is in the writings of Celsus around 100โCE, who described skin ulceration resulting from corrosive metals. The first accounts of occupational skin diseases focused on ill health among miners, and in 1556, Georg Agricola detailed the deep ulcers observed among metal workers. Eleven years later, Paracelsus discussed the etiology, pathogenesis, and therapy of skin changes caused by salt compounds. In 1700, Bernardino Ramazzini published a detailed treatise on the diseases of tradespeople in which he described skin disorders incurred by bath attendants, bakers, gilders, midwives, millers, and miners. Physicians began to more widely recognize occupational irritant dermatitis during the Industrial Revolution with the development of new materials and chemicals, both natural and synthetic, for industrial and household use. Germany and France were the first to enact laws compensating workers for industrial skin diseases.