๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
PATHOLOGY
The histopathologic features of ICD vary according to the nature of the irritant, but often include variable spongiosis, necrosis of keratinocytes, and an inflammatory infiltrate rich in neutrophils. The combination of a neutrophil-rich superficial perivascular infiltrate plus widely scattered necrotic keratinocytes is most typical; sometimes there is even fullthickness epidermal necrosis and subepidermal clefting. Mild ICD can resemble allergic contact dermatitis. Over time, additional histologic findings include acanthosis with mild hypergranulosis and hyperkeratosis. In aggregate, these elements are not specific, and they cannot be confidently differentiated from either chronic allergic contact dermatitis or other types of chronic eczemas.