๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Introduction
Brendon Verhave and Lisa A. Beck Eosinophil-Associated Dermatoses
Key features
ยInfiltration of eosinophils into the skin is not uncommon; therefore, clinicopathologic correlation is important to arrive at the correct clinical diagnosis
ยEosinophil-associated dermatoses include arthropod bite reactions and drug eruptions (โbugs and drugsโ), atopic dermatitis, Wells syndrome, hypereosinophilic syndromes, autoimmune blistering diseases, and parasitic infections
ยActivated eosinophils lose their morphologic integrity as they deposit toxic granule proteins and other inflammatory mediators in tissues; the absence of intact eosinophils may not be an accurate reflection of their relevance to a disease state
ยIn patients with persistent peripheral blood eosinophilia, as observed with hypereosinophilic syndromes, tissue infiltration and eosinophilderived mediators may cause significant end-organ damage