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DIFFERENTIAL DIAGNOSIS

The most important entity in the differential diagnosis of extragenital LS is morphea, and in the case of genital LS in girls and boys, sexual abuse. However, morphea and LS may coexist in the same patient. In adults, genital LS may mimic erosive lichen planus, mucous membrane pemphigoid, or erythroplasia of Queyrat (see Ch. 73). Distinction often requires histologic examination. Biopsies may also be needed to exclude associated differentiated VIN or invasive SCC. Histologically, LS-associated pseudoepitheliomatous hyperplasia has to be distinguished from SCC. A past history of allogeneic HSCT points to chronic GVHD that may be clinically and histologically indistinguishable from morphea or LS (see Fig. 44.16A).