๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
EPIDEMIOLOGY
Hyperlipidemia is quite common in the general population. In North America alone, it is estimated that over 100 million people currently have an elevated serum cholesterol level >200โmg/dl. Despite the large number of people who suffer from hyperlipidemia, only a minority will develop cutaneous xanthomas. Also, because the exact mechanism by which xanthomas form is not yet fully understood, it is not always possible to predict who will develop them. Xanthomas are thought to result from the permeation of circulating plasma lipoproteins through dermal capillary blood vessels followed by phagocytosis of the lipoproteins by macrophages, forming lipid-laden cells known as foam cells. However, the precise steps and their regulation are still an area of investigation.