Introduction
Foreign Body Reactions 94
M. Abdel Rahim Abdallah, Mahmoud M.A. Abdallah and Marwa Abdallah
Chapter Contents
Foreign Body Reactions to Inorganic and
Key features
Foreign body reactions represent inflammatory responses to inorganic and high-molecular-weight organic materials that have been introduced into the skin and are variably resistant to degradation
Routes of introduction can vary from accidental or self-inflicted to surgical and cosmetic procedures to topical application of various compounds
The most common clinical presentation is red to red–brown papules, nodules, or plaques (with or without ulceration) that are due to granulomatous inflammation
Less common clinical presentations include lichenoid and
pseudolymphomatous lesions, or the development of a fistula or draining wound
Histopathologic findings vary from granulomas (foreign body, sarcoidal, palisading) to lichenoid, eczematous, or pseudolymphomatous patterns
Diagnosis of foreign body reactions requires a high index of suspicion, thorough history, recognition of distinctive distribution patterns, and histologic examination (including polarized microscopy)