HISTORY
In 1916, Kyrle reported a diabetic woman with generalized hyperkeratotic nodules, which he called “hyperkeratosis follicularis et parafollicularis in cutem penetrans”. Lutz first described EPS as “keratosis follicularis serpiginosa” in 1953, and, in 1955, Miescher described the histologic findings, naming it “elastoma intrapapillare perforans verruciforme”. Mehregan, Schwartz, and Livingood reported the first child with RPC in 1967. A year later, Mehregan and Coskey expanded the concept of perforating disease to include perforating folliculitis in their article.