๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
PATHOLOGY
Although sometimes subtle, histopathologic features of the underlying disease are present in about two-thirds of patients (see Tables 10.1 and 10.2). As a result, biopsy specimens in one-third of individuals with erythrodermic MF or Sรฉzary syndrome are non-diagnostic. Of note, epidermotropism of neoplastic lymphocytes is less commonly observed in these two disorders than in conventional MF. Diagnostic findings are frequently found in psoriatic erythroderma, but less often in PRP.
It is important to remember that concurrent topical or systemic therapies as well as superimposed phenomena, e.g. atopic diathesis, contact dermatitis, impetiginization, can modify the histopathologic findings. In addition, multiple and sequential biopsies are often necessary in the evaluation of erythroderma.
Table 10.1 Causes of erythroderma in adults.