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INTRODUCTION
There are two concerns in drug safety: drug reactions and drug inter-actions. When multiple medications are prescribed, drug interactions become an important safety and efficacy consideration for patients and physicians alike. Non-prescription drugs, in addition to herbal supplements and alternative medicines as well as foods (such as grapefruit juice), may also be implicated in interactions with drug therapy.
It is difficult to obtain precise rates of incidence and prevalence, as specific diagnostic codes for drug interactions are lacking1a. This may be due to the fact that interactions can affect multiple processes by which drugs are absorbed, distributed, bound by plasma proteins, metabolized, and excreted, i.e. pharmacokinetic drug interactions. The drug interaction prevalence rate for hospitalized patients is about 1.1%, but differs considerably amongst medical disciplines. Every second dermatologic inpatient has a potential risk for relevant drug interactions, but one has to keep in mind that potential drug interactions far outnumber actual drug interactions.
Although it is impossible to remember all potential drug interactions, knowledge of the interactive properties of drugs can help reduce the risk of serious adverse outcomes. Moreover, it is the responsibility of physicians to counsel patients regarding drug interactions. Unfortunately, even when serious new drug interactions are recognized and reported, physicians, pharmacists, and patients are often unaware that there is aย risk.