๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
PUTTING INTERACTIONS INTO PERSPECTIVE
While most drugs are associated with interactions, many do not produce significant outcomes. In fact, not all listed or reported drug interactions are actually clinically significant. Whereas some have little clinical relevance, others are clearly defined as contraindications on the basis of substantiation of risk, potential severity, and frequency of occurrence. Still others can be successfully managed by dosage adjustment and monitoring. In other words, prescribing drugs with the potential for a deleterious interaction increases the risk of, but need not lead to, an adverse outcome.
In one study that examined the occurrence of drug interactions, based upon adverse events reported during large clinical trials, the authors concluded that serious adverse drug reactions (ADRs) secondary to drugโ drug interactions were infrequent; however, drugโdrug interactions that involved selected drugs with a narrow therapeutic index (which elicited life-threatening undesired effects) did occur. Drugโdrug interactions are the most common cause of medication errors in high-income countries, with a prevalence of 20%โ40%, especially due to polypharmacy in the elderly. Thus, for most drug interactions, it is necessary to assess each patient situation individually.