๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Introduction
Sabine A. Eming Biology of Wound Healing 141
Key features
ยWound healing is a complex and dynamic biologic process, with consecutive cascades consisting of early-stage coagulation and inflammation, intermediate tissue formation and proliferation, and late-stage resolution and tissue remodeling
ยEffective wound healing requires spatial and temporal synchro- nization of cellโcell and cellโmatrix interactions as well as an interplay of nutrients, metabolites, and cytokines
ยExtracellular matrix proteins are multifunctional molecules that bind directly to cell surface receptors (e.g. integrins); in addition to tissue stability and dynamics, matrix proteins influence cellular growth factor signaling (e.g. VEGF, TGF-ฮฒ)
ยIn children and adults, cutaneous wound healing represents a reparative process that can lead to fibrosis (scar), whereas injured fetal tissue can heal without fibrosis, in a process resembling regeneration
ยSeveral medical disorders (e.g. venous hypertension, atheroscle- rosis, diabetes mellitus, autoimmune inflammatory diseases) as well as local (e.g. pressure, infection) and systemic (e.g. aging) factors are associated with chronic non-healing wounds