BULLOUS DRUG ERUPTIONS
Key features
Some drug eruptions can present as blistering eruptions
These eruptions can be localized or widespread
Clinical, histologic, and immunofluorescence findings vary, depending on the type of drug eruption
Vesicles and bullae can develop in a variety of drug eruptions, which are outlined in Table 33.1 and discussed in detail in other chapters.
Table 33.1 Bullous drug eruptions. Occasionally, eczematous drug reactions (e.g. secondary to warfarin, calcium channel blockers, angiotensin converting enzyme [ACE] inhibitors, angiotensin II receptor blockers) and systemic contact dermatitis can be papulovesicular; patients with drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS) and drug-induced Sweet syndrome can also develop vesicles. Coma blisters and bullous small vessel vasculitis are discussed in the text. EGFR, epidermal growth factor receptor; NSAIDs, nonsteroidal anti-inflammatory drugs.