๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Introduction
Ronald P. Rapini Perforating Diseases 96
Synonyms:๏ก Hyperkeratosis follicularis et parafollicularis in cutem penetrans: Kyrle disease ๏ก Acquired perforating dermatosis: acquired reactive perforating collagenosis, acquired reactive perforating dermatosis, perforating disorder of uremia
Key features
ยGroup of disorders with transepidermal elimination of collagen, elastic tissue, or necrotic dermal connective tissue
ยPapules or nodules with keratotic plugs
ยElastosis perforans serpiginosa is associated with genetic diseases or penicillamine administration and involves elastic tissue; lesions are typically annular and most commonly occur in flexural sites, in particular the neck
ยReactive perforating collagenosis occurs after minor trauma, involves collagen, and often involves the upper extremities
ยAcquired perforating dermatosis is almost always associated with diabetes mellitus and/or the pruritus of chronic kidney disease (stages 4โ5); it favors the lower extremities of adults
ยBroadband or narrowband UVB phototherapy appears to be the most effective treatment for acquired perforating dermatosis