未來方向（FUTURE DIRECTIONS）
對照試驗與累積的臨床經驗持續重新界定 PDT 應用的範疇。即將到來的是新的光敏化劑與遞送 ALA 的創新方式。自 D-PDT 所獲得的知識（包括相關疼痛較少）已促成以低輻照度 LED 光源取代傳統光源的研究。PDT 的進展伴隨著影像技術如共焦反射顯微術 (confocal reflectance microscopy) 的進步。兩者未來的結合可能促成皮膚癌的非侵入性診斷與範圍界定，以及治療與長期評估。
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Light fractionation significantly improves the response
適應症與由個別執業醫師的經驗及經驗性偏好所引導的特定操作步驟。一輪外用藥物加上光（以單次暴露或多次分割暴露方式給予）可被視為一次 PDT 療程。一個 PDT「course」或「cycle」可能包含一次或多次以固定時間間隔分隔的個別 PDT 療程。不該被低估的是，提供適當的病人諮詢與衛教，以及在光暴露階段提供術中支援與監督所需的時間與人力。已有來自各專家團體與皮膚科學會的共識建議與指引發表，以指導 PDT 的使用。
圖 135-8：光化性角化症接受光動力療法（photodynamic therapy, PDT）後 4 天出現的紅斑、水腫與多發膿疱。外用 20% 5-aminolevulinic acid（ALA）後接續以 LED（發光二極體）紅光照射。