๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Introduction
Roy K.W. Chan, Martin T.W. Chio and Hong Yi Koh Cutaneous Manifestations of HIV Infection
Key features
ยA broad spectrum of infectious, inflammatory, and neoplastic skin conditions may occur in the setting of HIV-induced immune dysfunction
ยThe cutaneous findings often correlate with immune status, and knowing the viral load and CD4+ T cell count can help to generate a more focused differential diagnosis
ยThe possibility of HIV infection should be considered when patients present with severe, unusual, and treatment-resistant skin conditions; examples include giant molluscum contagiosum, extensive seborrheic dermatitis, and refractory herpes simplex virus infection
ยFollowing initiation of antiretroviral therapy (ART), skin disorders such as herpes zoster and Mycobacterium avium complex infection may become clinically apparent or worsen when the immune status improves, a phenomenon known as the immune reconstitution inflammatory syndrome (IRIS)
ยAlthough ART has led to a reduction in the frequency of severe opportunistic infections and skin conditions associated with advanced HIV disease, e.g. Kaposi sarcoma, other dermatologic problems have become more common, e.g. lipodystrophy, neoplasia related to human papillomavirus infection
ยThe medications used in ART can lead to drug eruptions, and HLA testing prior to initiating therapy may help predict the likelihood of a severe cutaneous adverse reaction